The Catalytic Switch ('Get bonus DNA from popping blue cure bubbles') gene is also incredibly useful late-game for all disease types.ĭo not fast forward at the beginning of the game, otherwise you might miss some precious DNA points. The key to my strategy is to use the Patho-stasis ('Ability costs don't increase but easier to cure') gene because it relies on maxing its Spore ability to infect all the countries. I have a strategy that can let you beat it on Mega Brutal. Investing a few points in abilities that make researching for the cure harder is fine, but I would rather invest in symptoms that have chances of killing instead. I personally get the Respiratory track (!) and work my way to Coma and Paralysis. Once everyone is infected, and at this point, you should have 70+ points, start putting points in the Symptoms. This is random, though, and it doesn't work at times, so use it only if there are a few countries left. If you are having trouble actually getting the fungus to some countries (Greenland I'm looking at you), invest a few points in the fungus special. If you're having trouble spreading in 1st world countries, invest one or two levels in the ability which makes drugs less effective.

Mutations will come, but de-evolve them ASAP and get free points to boot. Personally, I maximize Bird, Livestock, Air, and Water transmissions. Which transmission type depends on which country you start on. The starting area is not that important, but I usually choose one of the African countries since land-based transmission is prioritized.Ĭoncentrate on transmissions first. This WILL be a long game, so I advise playing at the fastest speed.

The trick is to spread the disease first to all of humanity before you raise their suspicion.

Plague inc fungus